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KMID : 0882420200950060404
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Korean Journal of Medicine
2020 Volume.95 No. 6 p.404 ~ p.408
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Acute Kidney Injury after Administering Dapagliflozin to a Diabetic Patient with Acute Cerebral Infarction
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Park Chang-Hyun
Lee Eun-Kyoung
Kim So-Mi
Cho Jong-Tae
Lee Do-Hyun
Lee Ji-Eun
Jeon Ji-Hyun
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Abstract
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Dapagliflozin is a recently developed oral anti-diabetic drug and SGLT2 inhibitor with well-known cardioprotective and renoprotective effects. Although a reduction of the glomerular filtration rate is induced by volume depletion and tubule-glomerular feedback during the early period after administering a SGLT2 inhibitor, the renal prognosis improves more with a decrease of proteinuria. However, the risk of acute kidney injury increases in heart failure and hypovolemia patients, and in those taking certain drugs, such as non-steroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers, or diuretics. We report acute kidney injury after dapagliflozin administration in a diabetic patient with acute cerebral infarction accompanied by right hemiplegia, motor aphasia, and dysphagia.
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KEYWORD
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Dapagliflozin, Acute kidney injury, Cerebral infarction
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